Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio

Almaida Pagán, Pedro Francisco; Lucas-Sanchez, A; Tocher, D R

Publication:
Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio

dc.contributor.author	Almaida Pagán, Pedro Francisco
dc.contributor.author	Lucas-Sanchez, A
dc.contributor.author	Tocher, D R
dc.contributor.department	Fisiología
dc.date.accessioned	2024-06-18T11:36:13Z
dc.date.available	2024-06-18T11:36:13Z
dc.date.issued	2014-04-24
dc.description	© 2014 Elsevier B.V This document is the Published version of a Published Work that appeared in final form in Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. To access the final edited and published work see https://doi.org/10.1016/j.bbalip.2014.04.004
dc.description.abstract	Considering membranes and membrane components as possible pacemakers of the main processes taking place inside mitochondria, changes in phospholipids or fatty acids could play a central role linking different mechanisms involved in cumulative damage to cell molecules and dysfunction during periods of high stress, such as rapid growth and aging. Changes affecting either lipid class or fatty acid compositions could affect phospholipid and membrane properties and alter mitochondrial function and cell viability. In the present study, mitochondrial oxidative status and mitochondrial membrane phospholipid compositions were analyzed throughout the lifecycle of zebrafish. TBARS content significantly increased in 18-month-old fish while aconitase activity decreased in 24-month-old fish, which have been related with oxidative damage to molecules. Mitochondria-specific superoxide dismutase decreased in 24-month-old animals although this change was not statistically significant. Age affected both mitochondrial phospholipid content and the peroxidation index of most phospholipid classes suggesting that oxidative damage to mitochondrial lipids was occurring.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids Volume 1841, Issue 7, July 2014, Pages 1003-1011
dc.identifier.doi	https://doi.org/10.1016/j.bbalip.2014.04.004
dc.identifier.issn	Print: 1388-1981
dc.identifier.uri	http://hdl.handle.net/10201/142392
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	This research and P.F.A.-P. were funded by a Marie Curie Intra-European Fellowship within the 7th Community Framework Programme (PIEF-GA-2011-297964, OLDMITO). A. L.-S. was funded by Instituto de Salud Carlos III (RETICEF, RD12/0043/0011) and by Fundación Séneca (12005/PI/09).	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1388198114000791	es
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Aging	es
dc.subject	Cardiolipin
dc.subject	Fatty acid
dc.subject	Mitochondrion
dc.subject	Danio rerio
dc.subject	Oxidative stress
dc.title	Changes in mitochondrial membrane composition and oxidative status during rapid growth, maturation and aging in zebrafish, Danio rerio	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es