Publication: The role of gicerin, a novel cell adhesion molecule, in development, regeneration and neoplasia
Authors
Tsukamoto, Y. ; Taira, E. ; Miki, N. ; Sasaki, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neurite outgrowth factor (NOF) is an
extracellular matrix (ECM) protein in the laminin family
and its ligand, gicerin, is a novel cell adhesion molecule
in the immunoglobulin superfamily. Gicerin has a
homophilic adhesive activity as well as a heterotypic
manner to NOF. In the nervous systems, gicerin is
expressed during developmental stage when neurons
migrate or extend neurites to form a neural network.
Gicerin promotes neurite extension and migration of
embryonic neurons in vitro by its homophilic and
heterophilic adhesion activities. Introduction of antigicerin
antibody into early developing eyes perturbs the
layer formation of neural retina. These data suggest that
gicerin participates in the formation of neural tissues.
Gicerin is also expressed in other non-neural tissues; in
epithelia of trachea, kidney and oviduct, gicerin
expression is restricted in the developmental period. In
contrast, muscular tissues and endothelial cells express
gicerin continuously even after maturation. Interestingly,
gicerin re-appears strongly in the regenerating epithelia
of trachea, kidney and oviduct, and also anti-gicerin
antibody disrupts the healing process of trachea.
Furthermore, gicerin and NOF are overexpressed in the
chicken nephroblastomas (Wilm's tumor) and oviductal
adenocarcinomas. In vitro analyses show that gicerin
adhesive activities can promote binding among tumor
cells and adhesion of tumor cells to NOF. A polyclonal
antibody against gicerin also perturbs the re-attachment of cancer cells onto metastasizing sites. It is clear from
these studies that gicerin is a potential effector for
pathological tissue formation as well as for normal
development.
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