Publication:
Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

Simple item page
dc.contributor.authorMartín Sánchez, María Rosario Fátima
dc.contributor.authorTyrkalska, Sylwia D.
dc.contributor.authorCandel Camacho, Sergio
dc.contributor.authorAngosto, Diego
dc.contributor.authorGómez Abellán, Victoria
dc.contributor.authorGarcía Moreno, Diana
dc.contributor.authorZapata Pérez, Rubén
dc.contributor.authorSánchez Ferrer, Álvaro
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.authorMulero Méndez, Victoriano Francisco
dc.contributor.authorSepulcre Cortés, María Pilar
dc.contributor.departmentFarmacología
dc.date.accessioned2026-02-26T18:41:58Z
dc.date.available2026-02-26T18:41:58Z
dc.date.copyright© 2016, The Author(s)
dc.date.issued2016-07-01
dc.description.abstractInflammasomes are cytosolic molecular platforms that alert the immune system about thepresence of infection. Here we report that zebrafish guanylate-binding protein 4 (Gbp4),an IFNg-inducible GTPase protein harbouring a C-terminal CARD domain, is required for theinflammasome-dependent clearance of Salmonella Typhimurium (ST) by neutrophils in vivo.Despite the presence of the CARD domain, Gbp4 requires the universal inflammasomeadaptor Asc for mediating its antibacterial function. In addition, the GTPase activity of Gbp4is indispensable for inflammasome activation and ST clearance. Mechanistically, neutrophilsare recruited to the infection site through the inflammasome-independent production of thechemokine (CXC motif) ligand 8 and leukotriene B4, and then mediate bacterial clearancethrough the Gbp4 inflammasome-dependent biosynthesis of prostaglandin D2. Our resultspoint to GBPs as key inflammasome adaptors required for prostaglandin biosynthesis andbacterial clearance by neutrophils and suggest that transient activation of the inflammasomemay be used to treat bacterial infections.
dc.formatapplication/pdf
dc.format.extent17
dc.identifier.citationNat Commun 7, 12077 (2016)
dc.identifier.doihttps://doi.org/10.1038/ncomms12077
dc.identifier.eissn2041-1723
dc.identifier.urihttp://hdl.handle.net/10201/215221
dc.languageeng
dc.publisherNature Research
dc.relationEste trabajo ha sido financiado por: - European 7th Framework Initial Training Network FishForPharma (PITG-GA-2011-289209) - Ministerio de Economia y Competitividad (BIO2014-52655-R) - Seventh Framework Programme (UE) (614578) - European Research Council (UE) - Instituto de Salud Carlos III (CD12/00523)
dc.relation.publisherversionhttps://www.nature.com/articles/ncomms12077
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBacterial infection
dc.subjectInflammasome
dc.subjectMedical research
dc.subjectNeutrophils
dc.subject.odsObjetivo 3: Salud
dc.titleNeutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationeefc2e40-b110-47b5-a081-bcf37256af4c
relation.isAuthorOfPublicationd589b7ec-663f-4d7a-bdf5-78eba47d1372
relation.isAuthorOfPublicationaa6ca3f7-ee95-4c3b-b93d-82bbb7c57dd3
relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication369f9ade-8896-4d91-84c5-e3f94a526070
relation.isAuthorOfPublication508910a4-32ba-4c84-8616-ea6c14c4f883
relation.isAuthorOfPublication.latestForDiscoveryeefc2e40-b110-47b5-a081-bcf37256af4c
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Neutrophils mediate Salmonella Typhimuriumclearance through the GBP4 inflammasome-dependent production of prostaglandins_nature comm-2016.pdf
Size:
2.79 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos