Publication: Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy
Authors
Shi, J.J. ; Ma, X.H. ; Diao, H.L. ; Ni, H. ; Xu, L.B. ; Zhu, H. ; Yang, Z.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
PGE2 is essential for mammalian female
reproduction. This study was to examine the expression
of EP2 gene in the rat uterus during early pregnancy,
delayed implantation and artificial decidualization by in
situ hybridization and immunohistochemistry. There was
no detectable EP2 mRNA expression in the uterus from
days 1 to 4 of pregnancy (day 1 = day of vaginal sperm).
A low level of EP2 immunostaining was observed in the
luminal and glandular epithelium from days 1 to 4 of
pregnancy. Both EP2 mRNA and protein expression
were highly detected in the luminal epithelium at
implantation sites on day 6 of pregnancy. EP2
expression decreased from day 7 of pregnancy and was
undetectable on days 8 and 9 of pregnancy. After
delayed implantation was terminated by estrogen
treatment and the embryo implanted, both EP2 mRNA
and protein expression were strongly observed in the
luminal epithelium at the implantation site. There was no
detectable EP2 expression in both control and
decidualized uteri. In conclusion, these data suggest that
EP2 expression at implantation site may play an
important role during embryo implantation in rats.
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