Publication:
Child head circumference and placental MFSD2a expression are associated to the level of MFSD2a in maternal blood during pregnancy

Simple item page
dc.contributor.authorSánchez-Campillo, María
dc.contributor.authorRuiz-Palacios, María
dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorBlanco Carnero, José Eliseo
dc.contributor.authorPrieto Sánchez, María Teresa
dc.contributor.authorZornoza, Matilde
dc.contributor.authorRuiz-Pastor, María José
dc.contributor.authorDemmelmair, Hans
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.authorKoletzko, Berthold
dc.contributor.authorLarqué Daza, Elvira
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-13T08:10:25Z
dc.date.available2026-01-13T08:10:25Z
dc.date.copyright© 2020 los autores
dc.date.issued2020-02-05
dc.description.abstractGestational diabetes mellitus (GDM) is a world-wide health challenge, which prevalence is expected to increase in parallel to the epidemic of obesity. Children born from GDM mothers have lower levels of docosahexaenoic acid (DHA) in cord blood, which might influence their neurodevelopment. Recently, the membrane transporter Major Family Super Domain 2a (MFSD2a) was associated with the selective transportation of DHA as lysophospholipids. The expression of the DHA membrane transporter MFSD2a is lower in GDM placentas, which could affect materno-fetal DHA transport. Humans with homozygous inactivating mutations in the MFSD2a gene present severe microcephalyand intellectual impairments. Herein, we intended to identify early blood biomarkers that maybeofuse during pregnancy to monitor the offspring development and the adequate nutritional interventions, such as nutritional supplementation, that may be selected to improve it. We evaluated MFSD2a expression in maternal blood at the third trimester of pregnancy, and its potential relationship with the expression of placental MFSD2a at delivery and child outcomes. Three groups of pregnant women were recruited: 25 controls, 23 GDM with dietary treatment, and 20 GDM with insulin treatment. Maternal and neonatal anthropometric and biochemical parameters were evaluated. MFSD2a was analyzed in placenta, blood and serum. MFSD2a protein expression in maternal blood was significantly lower in GDM groups and correlated with placental MFSD2a and Z-score neonatal head circumference during the first 6 months of life. The cord/maternal serum ratio of DHA, a solid indicator of materno-fetal DHA transport, was reduced in GDMgroups and correlated with MFSD2a in maternal blood at the third trimester and in placenta at delivery. This indicates that altered MFSD2a levels in maternal blood during pregnancy might influence placental nutrient transport and fetal neurodevelopment. Furthermore, MFSD2a levels in maternal blood on the third trimester were inversely correlated to DHA in maternal serum lyso-PL. Thus, the level of MFSD2a in maternal blood could be used as a potential biomarker for the early detection of disturbances of MFSD2a expression during pregnancy and the subsequent consequences for the neurodevelopment of the child, as well as it may help to choose the optimal treatment approach for the affected subjects.
dc.formatapplication/pdf
dc.format.extent11
dc.identifier.citationFront. Endocrinol. 11:38
dc.identifier.doihttps://doi.org/10.3389/fendo.2020.00038
dc.identifier.eissn1664-2392
dc.identifier.urihttp://hdl.handle.net/10201/186069
dc.languageeng
dc.publisherFrontiers Media
dc.relationThe authors declare that this study received funding from HERO S.L. Spain. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. Further partial financial support was provided by the Commission of the European Communities, the 7th Framework Programme, contract FP7-289346-EARLY NUTRITION, the Excellence Network for Maternal and Child Health and Development (RED SAMID III, 16/0022/0009), and the Research Excellence Group CHRONOHEALTH (19899/GERM/15).
dc.relation.publisherversionhttps://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2020.00038/full
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGestational diabetes mellitus
dc.subjectNeurodevelopment
dc.subjectBiomarkers
dc.subjectMFSD2a
dc.subjectFatty acids transport
dc.subjectDocosahexaenoic acid
dc.subjectPregnancy
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleChild head circumference and placental MFSD2a expression are associated to the level of MFSD2a in maternal blood during pregnancy
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc5d54ef3-bd3b-4330-b4a1-252ab278925b
relation.isAuthorOfPublicationcf258283-676e-4be7-bb49-4b0b8275b722
relation.isAuthorOfPublicationb616306e-86e0-4c17-aed3-fb394c718eb0
relation.isAuthorOfPublicationa20da46d-caef-436f-88c1-5ea0f45ce23e
relation.isAuthorOfPublication0f4b679f-bfec-4a3f-8065-bafb202353ab
relation.isAuthorOfPublication.latestForDiscoveryc5d54ef3-bd3b-4330-b4a1-252ab278925b
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
FrotEndocrinol 2020.pdf
Size:
670.47 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos