Publication: Evaluation of microvascular density in tumors, pro and contra
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Date
2008
Authors
Nico, Beatrice ; Benagiano, Vicenzo ; Mangieri, Doménica ; Maruotti, Nicola ; Vacca, Angelo ; Ribatti, Doménico
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Microvascular density (MVD) counting
protocols have become the morphological gold standard
to assess the neovasculature in human tumors. This
method requires the use of specific markers to vascular
endothelium and of immunohistochemical procedures to
visualize microvessels. MVD determined in primary
tumors is significantly associated with metastasis and
prognosis in several tumors and is most predictive in
those tumors that induce significant angiogenesis,
namely carcinomas of breast and prostate, and
haematological malignancies.
There is such a wide range of antibodies and
suppliers, antigen retrieval methods, designation of high
and low vessel count groups, patient study groups and
data interpretation, that it is exceedingly difficult to
compare results.
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Citation
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