Publication: Akt pathway as a target for therapeutic intervention in HNSCC
Authors
Moral, Marta ; Paramio, Jesús M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Head and neck squamous cell carcinoma
(HNSCC) is the sixth most common form of cancer
worldwide. One frequent alteration found in this type of
cancer is overactivation of the PI3K/PTEN/mTOR
pathway, of which protein kinase B (PKB)/Akt is a
central key element, controlling important cellular
processes such as metabolism, cell size, proliferation and
apoptosis, ultimately regulating cell growth and survival.
Thus, drugs that target Akt directly or elements of the
pathway are plausible candidates for cancer treatment.
Accordingly, numerous clinical trials in various phases
are being performed for these drugs. In this review, we
discuss the tumorigenic capacity of Akt and focus on its
role in HNSCC, paying special attention to the current
efforts in treating this cancer in a more specific, Akttargeted
way, based on its primordial role in this type of
cancer.
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