Metallic ion content and damage to the DNA in oral mucosacells of children with fixed orthodontic appliances

Fernández Miñano, Esther; Ortiz Ruiz, María Clara; Vicente, Ascensión; Calvo Guirado, José Luis; Ortiz Ruiz, Antonio José

Publication:
Metallic ion content and damage to the DNA in oral mucosacells of children with fixed orthodontic appliances

dc.contributor.author	Fernández Miñano, Esther
dc.contributor.author	Ortiz Ruiz, María Clara
dc.contributor.author	Vicente, Ascensión
dc.contributor.author	Calvo Guirado, José Luis
dc.contributor.author	Ortiz Ruiz, Antonio José
dc.contributor.department	Dermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned	2024-06-25T08:22:38Z
dc.date.available	2024-06-25T08:22:38Z
dc.date.issued	2011-04-06
dc.description	© Springer Science+Business Media, LLC. 2011. This document is the Published version of a Published Work that appeared in final form in BioMetals. To access the final edited and published work see https://doi.org/10.1007/s10534-011-9448-z
dc.description.abstract	Although the metal devices used in orthodontic treatments are manufactured highly resistance to corrosion, they may still suffer some localized corrosion resulting from the oral cavity conditions. The corrosion causes the release of metals from the alloys used for their manufacture. In this report, we evaluated the in vivo metal ions release of three alloys (stainless steel, titanium and nickel-free) usually used in the orthodontics treatments and its genotoxicity. We applied to 15 patients, between 12 and 16 years, 4 tubes and 20 brackets. Samples from oral mucosa were taken before the treatment and 30 days later. The concentration of the titanium, chromium, manganese, cobalt, nickel, molybdenum and iron were detected using inductively coupled plasma mass spectrometry (ICP-MS). The genotoxicity was measured with a comet assay (Olive moment). The oral mucosa cells in contact with the stainless steel alloy displayed the greatest titanium and manganese concentrations and those in contact with the nickel-free alloy presented the greatest concentration of chromium and iron. Both alloys, stainless steel and nickel-free, induced a higher DNA damage in the oral mucosa cells than the titanium alloy, in which the Olive moment was similar to controls. Based on the results of our study, we can conclude that titanium brackets and tubes are the most biocompatible of the three alloys.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.citation	Biometals (2011) 24:935–941
dc.identifier.doi	https://doi.org/10.1007/s10534-011-9448-z
dc.identifier.issn	Print: 0966-0844
dc.identifier.issn	Electronic: 1572-8773
dc.identifier.uri	http://hdl.handle.net/10201/142633
dc.language	eng	es
dc.publisher	Springer	es
dc.relation	Ámbito del proyecto: Regional. Agencia financiadora: FUNDACIÓN SÉNECA Convocatoria: 2007 Nombre del proyecto: ESTUDIOS "IN VIVO" E "IN VITRO" DE LA TOXICIDAD DE MATERIALES METÁLICOS USADOS EN LOS TRATAMIENTOS DE ORTODONCIA. Código o número del acuerdo de subvención: 05747/PPC/07-N. This work was financially supported by Seneca Foundation of the Region of Murcia (Spain) under a grant (nº 100260)	es
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s10534-011-9448-z
dc.rights	info:eu-repo/semantics/embargoedAccess	es
dc.subject	Orthodontic alloy	es
dc.subject	Metal toxicity	es
dc.subject	ICP-MS	es
dc.subject	DNA damage	es
dc.subject	Comet assay	es
dc.title	Metallic ion content and damage to the DNA in oral mucosacells of children with fixed orthodontic appliances	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es