Publication:
Androgen receptor mRNA under-expression in poorly differentiated human hepatocellular carcinoma

Simple item page
dc.contributor.authorTavian, D.es
dc.contributor.authorDe Petro, G.es
dc.contributor.authorPitozzi, A.
dc.contributor.authorPortolani, N.
dc.contributor.authorGiulini, S.M.
dc.contributor.authorBarlati, S.
dc.date.accessioned2011-05-11T10:59:15Z
dc.date.available2011-05-11T10:59:15Z
dc.date.issued2002
dc.description.abstractMany studies suggest that hepatocellular carcinoma (HCC) is an androgen-dependent tumor with an incidence five times higher in males, but few data are available on the androgen receptor (AR) mRNA levels in different physiological classes of human liver specimens. In this study 108 human hepatic samples have been analyzed for AR mRNA expression by a comparative RT-PCR assay. These consisted of 35 non-tumoral hepatic samples (3 normal parenchymas, 4 steatosis, 10 hepatitis, 18 cirrhosis), 38 tumoral specimens derived from uninodular and multinodular HCCs and 35 peritumoral hepatic tissues. Normalized AR mRNA levels in tumoral and peritumoral liver tissues spanned from 0 to 146% and from 7 to 125% respectively. Only in a relatively small percentage of HCCs, the levels of expression of AR mRNA were higher than in the corresponding peritumoral tissues (16% of total HCCs). Although extremely variable, the AR mRNA levels were related to histological tumoral differentiation and proved to be lower in the highly dedifferentiated HCCs as compared to the well differentiated ones. Therefore, the evaluation of AR expression in HCC patients might be relevant for the planning of clinical studies on anti-androgen therapies, which might be useful only in the cases in which a high level of AR mRNA is detected, considering the high heterogeneity of AR mRNA levels which characterizes HCC samples. It is likely that the HCCs, expressing low or undetectable levels of AR mRNA, would not benefit by the antiandrogen therapy.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20864
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHepatocellular carcinomaes
dc.subjectTumoral differentiationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleAndrogen receptor mRNA under-expression in poorly differentiated human hepatocellular carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Androgen receptor mRNA underexpression in.pdf
Size:
191.22 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.17, nº 4 (2002)