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Gender differences in the renal changes induced by a prolonged high-fat diet in rats altered renal developmet

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dc.contributor.authorMoreno, Juan Manuel
dc.contributor.authorDe Jódar, Carlos
dc.contributor.authorReverte, Virginia
dc.contributor.authorBernabé, Antonio
dc.contributor.authorSalazar, Francisco Javier
dc.contributor.authorLlinás Más, María Teresa
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.departmentFisiología
dc.date.accessioned2025-01-21T11:58:42Z
dc.date.available2025-01-21T11:58:42Z
dc.date.issued2021-08
dc.description.abstracthe mechanisms involved in renal dysfunction induced by high-fat diet (HFD) in subjects with altered renal development (ARDev) are understudied. The objective of this study is to examine whether there are sex-dependent differences in the mechanisms involved in the hypertension and deterioration of renal function in SD rats with prolonged HFD and ARDev. The role of angiotensin II (Ang II) in the arterial pressure (AP) increments, the renal hemodynamic sensitivity to Ang II, glomerular damage and changes in fat abdominal volume, plasma adipokine levels, renal NADPHp67phox expression, and renal infiltration of immune cells were examined. Hypertension and deterioration of renal function were enhanced (P < 0.05) in both sexes of rats with HFD and ARDev. The decrease (P < 0.05) of AP elicited by candesartan in hypertensive rats was similar to that induced by the simultaneous administration of candesartan and apocynin. The greater (P < 0.05) renal vasoconstriction induced by Ang II in both sexes of rats with HFD and ARDev was accompanied by an enhanced (P < 0.05) infiltration of CD-3 cells and macrophages in the renal cortex and renal medulla. The increments (P < 0.05) in the renal expression of NADPHp67phox and glomeruloesclerosis were greater (P < 0.05) in males than in females with HFD and ARDev. Our results suggest that the hypertension and deterioration of renal function induced by HFD in rats with ARDev are Ang II-dependent and mediated by increments in oxidative stress and immune system activation. Sex-dependent increments in oxidative stress and glomerular damage may contribute to the deterioration of renal function in these rats.es
dc.formatapplication/pdfes
dc.format.extent28es
dc.identifier.citationJournal of Physiology and Biochemistry, 2021, Vol. 77, pp. 431-441
dc.identifier.doihttps://doi.org/10.1007/s13105-021-00815-y
dc.identifier.issnPrint: 1138-7548
dc.identifier.issnElectronic: 1877-8755
dc.identifier.urihttp://hdl.handle.net/10201/148921
dc.languageenges
dc.relationEste trabajo ha contado con el apoyo del Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (PI16/01556) (cofinanciado por el Fondo Europeo de Desarrollo Regional/Fondo Social Europeo «Una manera de hacer Europa/Invertir en tu futuro) y Fondos FEDER.es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s13105-021-00815-yes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAngiotensin IIes
dc.subjectHigh fat dietes
dc.subjectHypertensiones
dc.subjectImmune systemes
dc.subjectOxidative stresses
dc.subjectRenal damagees
dc.subjectRenal developmentes
dc.titleGender differences in the renal changes induced by a prolonged high-fat diet in rats altered renal developmetes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationa11bfbe4-fe50-4173-a96d-aa785375a6be
relation.isAuthorOfPublication.latestForDiscoverya11bfbe4-fe50-4173-a96d-aa785375a6be
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