Publication: Frequent expression of haemopoietic and non-haemopoietic antigens by reactive plasma cells: an immunohistochemical study using formalin-fixed, paraffin-embedded tissue
Loading...
Date
1999
Authors
Beschorner, R. ; Horny, H.P. ; Petruch, U.R. ; Kaiserling, E.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Unlike other B cells, plasma cells (PC) react
with only a few antibodies against haemopoietic
antigens. We investigated 36 specimens exhibiting a
reactive increase in PC numbers (i.e. plasmacytosis, PC
hyperplasia) with a broad panel of antibodies suitable for
use on formalin-fixed, paraffin-embedded tissue, and
compared the findings with those obtained in 51 cases of
multiple myeloma (plasmacytoma).
Regardless of the immunostaining pattern for
immunoglobulin light and heavy chains, reactive PC
reacted with at least two and at most six of seventeen
antibodies detecting haemopoietic antigens [Ber-
H2lCD30 (91%), anti-leucocyte common antigen
(LCA)/CD45 (86%), KP1lCD68 (64%), MB2 (57%),
4KB51CD45RA (37%), DF-TllCD43 (28%), UCHL11
CD45RO (20%), L26lCD20 (17%), MT2 (14%) and
Mac387 (g%)], and with at least one and at most four of
six antibodies against non-haemopoietic antigens [antiepithelia1
membrane antigen (EMA) (94%), antivimentin
(77%), anti-pan-cytokeratinIKL1 (74%),
BMA120 (51%) and HMB45 (14%)].
Five antibodies stained reactive PC significantly
more often than neoplastic PC: Ber-H2lCD30
(ps 0.0000), KPllCD68 (ps 0.0000), anti-LCAlCD4.5
(ps 0.0000), anti-EMA (p5 0.0339) and anti-pancytokeratinIKL1
(ps 0.0000). The more frequent and
more heterogeneous expression of antigens by reactive
PC suggests that the aberrant immunoreactivity of neoplastic PC in plasmacytoma is not due to the process
of malignant transformation in an early step of B-cell
differentiation, but could reflect the heterogeneity of
antigen expression by normal PC.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.