Publication: C-reactive protein and atherosclerosis.
Is there a causal link?
Authors
Manolov, D.E. ; Koenig, W. ; Hombach, V. ; Torzewski, J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
C-reactive protein (CRP) is a powerful
cardiovascular risk marker. Evidence suggests that this
may be due to its direct proatherogenic properties.
Because of different biological functions of CRP in
different species, an appropriate animal model for the
study of its role in atherogenesis is difficult to set up.
Binding to low density lipoprotein (LDL), activation of
the complement system and interaction with
monocyte/macrophages are rigorously defined
pathogenic properties of CRP which might contribute to
an active role of the molecule in human atherogenesis.
Furthermore, direct effects on arterial wall cells, i.e.
endothelial cells and smooth muscle cells, have been
reported. The molecular basis of CRP interaction with
these cells, however, remains unclear. Should CRP
indeed be actively involved in human atherogenesis, the
molecule may become a target for therapy.
Pharmaceutical companies develop CRP-inhibitors.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.