Publication: Skeletal muscle development in the mouse embryo
Authors
Kablar, B. ; Rudnicki, M.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
n this review we discuss the recent findings
concerning the mechanisms that restrict somitic cells to
the skeletal muscle fate, the myogenic regulatory factors
controlling skeletal muscle differentiation and
specification of myogenic cell lineages, the nature of
inductive signals and the role of secreted proteins in
embryonic patterning of the myotome. More specifically,
we review data which strongly support the hypothesis
that Myf-5 plays a unique role in development of epaxial
muscle, that MyoD plays a unique role in development
of hypaxial muscles derived from migratory myogenic
precursor cells, and that both genes are responsible for
development of intercostal and abdominal muscles
(hypaxial muscles that develop from the dermatomal
epithelia). In addition, while discussing upstream and
post-translational regulation of myogenic regulatory
factors (MRFs), we suggest that correct formation of the
myotome requires a complex cooperation of DNA
binding proteins and cofactors, as well as inhibitory
function of non-muscle cells of the forming somite,
whose proteins would sequester and suppress the
transcription of MRFs. Moreover, in the third part of our
review, we discuss embryonic structures, secreted
proteins and myogenic induction. However, although
different signaling molecules with activity in the process
of somite patterning have been identified, not many of
them are found to be necessary during in vivo embryonic
development. To understand their functions, generation
of multiple mutants or conditional/tissue-specific
mutants will be necessary.
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