Publication: Ultrastructure of murine cardiac ganglia in experimental Chagas's disease
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Date
1992
Authors
Wong, W. C. ; Tan, C.K. ; Singh, M. ; Yick, T. Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Albino mice, infected with Trypanosoma
cruzi (Tulahuen strain) were sacrificed on days 7, 9, 12,
14, 16, 18, 21, 32 and 39 following infection.
Transmission electron microscopic examination of the
cardiac ganglia revealed no ultrastructural change at day
7. At day 9 there was peri- and intraganglionic
monocytic infiltration but parasites were absent.
Between days 12 and 16 there was intense monocytic
infiltration, with intra-ganglionic presence of parasites
within fibroblasts, monocytes and macrophages. None
were seen within capsular cells, endothelial cells,
Schwann cells, statellite cells and ganglion cells. The
Schwann cells and satellite cells, however, showed
phagocytic activity. Satellite cells were also reactive
with proliferative pseudopodia which encircled neuronal
processes. By day 18, parasites were absent in the
ganglia. But monocytes were still present up to day 39,
some of them still engulfing satellite cell and neuronal
processes. Satellite cells continued to be reactive and
Schwann cells phagocytic. Ganglion cells remained
normal throughout the experiment.The results suggest
that infection of Schwann cells, satellite cells and
ganglion cells may depend upon the tissue tropism of
the strain of the parasite used and its concentration in
the inoculum. The results are consistent with the view
that any parasympathetic dysfunction in experimental
Chaga's disease in the mouse may be of a transient
nature.
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