Publication:
Extracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: An immunohistochemical study

Simple item page
dc.contributor.authorStröm, Å.es
dc.contributor.authorAhlqvist, E.es
dc.contributor.authorFranzé, Adela
dc.contributor.authorHeinegård, D.
dc.contributor.authorHultghrdh-Nilsson, A.
dc.date.accessioned2011-06-08T09:08:20Z
dc.date.available2011-06-08T09:08:20Z
dc.date.issued2004
dc.description.abstractDuring accelerated vascular remodeling such as in atherosclerosis, the composition of the extracellular matrix becomes altered. The matrix components of the diseased artery influence cellular processes such as adhesion, migration and proliferation. Furthermore, in atherosclerosis, the inability of the cells within the lesion to produce a mechanically stable matrix may lead to plaque rupture. In this immunohistochemical study of atherosclerotic mice aorta, we have reviewed the presence of ECM components with roles in maintaining tissue structure and function. These components include osteopontin and COMP as well as the leucine rich repeats proteins decorin, PRELP, and fibromodulin. Immunohistochemistry demonstrated presence of osteopontin, COMP, decorin, PRELP and fibromodulin in lesion areas of ApoE/LDLr deficient mice. Some advanced lesions exhibited areas of cartilage-like morphology and were shown to represent cartilage by their content of the cartilage specific proteins collagen II and aggrecan. The results suggest that cartilageassociated cell/collagen binding ECM proteins may be involved in the pathogenesis of atherosclerosis.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21558
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAtherosclerosises
dc.subjectExtracellular matrixes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleExtracellular matrix components in atherosclerotic arteries of Apo E/LDL receptor deficient mice: An immunohistochemical studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Extracellular matrix components in.pdf
Size:
23.41 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.19, nº 2 (2004)