Publication:
Age-related changes in mitochondrial membrane composition of nothobranchius rachovii

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dc.contributor.authorLucas-Sánchez, Alejandro
dc.contributor.authorAlmaida Pagán, Pedro Francisco
dc.contributor.authorTocher, Douglas R.
dc.contributor.authorMendiola, Pilar
dc.contributor.authorCosta, Jorge de
dc.contributor.departmentFisiología
dc.date.accessioned2024-06-19T10:55:51Z
dc.date.available2024-06-19T10:55:51Z
dc.date.issued2013-05-17
dc.description©The Author 2013. This document is the Published version of a Published Work that appeared in final form in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. To access the final edited and published work see https://doi.org/10.1093/gerona/glt066
dc.description.abstractMitochondrial membrane composition may be a critical factor in the mechanisms of the aging process by influencing the propagation of reactions involved in mitochondrial function during periods of high stress. Changes affecting either lipid class or fatty acid compositions could affect phospholipid properties and alter mitochondrial function and cell viability In the present study, mitochondrial membrane phospholipid compositions were analyzed throughout the life cycle of Nothobranchius rachovii. Mitochondrial phospholipids showed several changes with age. Proportions of cardiolipin decreased and those of sphingomyelin increased between 11- and 14-month-old fish. Fatty acid compositions of individual phospholipids in mitochondria were also significantly affected with age. These data suggest increasing damage to mitochondrial lipids during the life cycle of N. rachovii that could be one of the main factors related with and contributing to degraded mitochondrial function associated with the aging process.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationJ Gerontol A Biol Sci Med Sci 2014 February 69(2):142–151
dc.identifier.doihttps://doi.org/10.1093/gerona/glt066
dc.identifier.issnPrint: 1079-5006
dc.identifier.issnElectronic: 1758-535X
dc.identifier.urihttp://hdl.handle.net/10201/142433
dc.languageenges
dc.publisherOxford University Presses
dc.relationThis project was funded by Fundación Seneca (12005/PI/09), Instituto de Salud Carlos III (RETICEF, RD12/0043/0011), and Ministerio de Educación y Ciencia (BFU2010-21945-C02-01). P.F.A.-P. was funded by Fundación Ramón Areces and an Intra European Fellowship within the 7th Community Framework Programme (PIEF-GA-2011-297964, OLDMITO).es
dc.relation.publisherversionhttps://academic.oup.com/biomedgerontology/article/69A/2/142/514518
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAginges
dc.subjectMitochondria
dc.subjectPhospholipid
dc.subjectFatty acid
dc.subjectFish
dc.titleAge-related changes in mitochondrial membrane composition of nothobranchius rachoviies
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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