Publication: Emerging biological functions of the Vaccinia-Related Kinase (VRK) family
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Date
2009
Authors
Klerkx, Elke P.F. ; Lazo, Pedro A. ; Askjaer, Peter
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Vaccinia-Related Kinases (VRKs)
branched off early from the family of casein kinase (CK)
I and compose a relatively uncharacterized family of the
kinome. The VRKs were discovered due to their close
sequence relation to the vaccinia virus B1R
serine/threonine kinase. They were first described in
phosphorylation of transcription factors that led to the
discovery of an autoregulatory mechanism between
VRK and the tumor suppressor transcription factor p53.
The relevance of VRKs has broadened recently by
introduction of its members as essential regulators in cell
signaling, nuclear envelope dynamics, chromatin
modifications, apoptosis and cellular stress response.
Several phosphorylation substrates have been described,
as well as the first positive and negative regulators of
VRK. We provide an overview of the VRKs across
species and discuss the wide diversity of cellular and
organismal requirements for this kinase family.
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