Publication:
Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer

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dc.contributor.authorLi, Shuai
dc.contributor.authorMa, Yulian
dc.contributor.authorWu, Chen
dc.contributor.authorHou, Xinfang
dc.date.accessioned2023-09-11T07:30:39Z
dc.date.available2023-09-11T07:30:39Z
dc.date.issued2023
dc.description.abstractKinesin family member 2C (KIF2C) was reported to act as a vital player in several human cancers. However, the exact function of KIF2C in gastric cancer (GC) is poorly understood. In the present study, the potential role of KIF2C was studied in gastric cancer by bioinformatics analysis and proliferation assay. KIF2C expression was detected using reverse transcription-quantitative polymerase chain reaction and western blot. Our data showed that the expression of KIF2C was increased in different tumor tissues, including GC. KIF2C was overexpressed in GC tissues and might be used as a diagnostic and prognostic biomarker for GC. KIF2C expression was correlated with immune infiltration and the levels of cell cyclerelated genes in GC. Moreover, silencing of KIF2C can cause cell cycle arrest, and inhibit the proliferative ability of GC cells. Thus, our studies revealed that KIF2C levels might serve as a promising biomarker for diagnosis and prediction of prognosis of GC, and targeting KIF2C might be an effective therapeutic strategy for GC.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifierHistology and Histopathology Vol. 38, nº8 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-556
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/133783
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKinesin family member 2Ces
dc.subjectGastric canceres
dc.subjectCell cycle arrestes
dc.subjectImmune infiltrationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleKnockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº8 (2023)