Publication: Regulated expression of galectin-3,
a multifunctional glycan-binding protein, in
haematopoietic and non-haematopoietic tissues
Authors
Sundblad, Victoria ; Croci, Diego O. ; Rabinovich, Gabriel A.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Galectin-3 belongs to a family of highly
conserved animal lectins characterized by their ability to
recognize multiple N-acetyllactosamine sequences,
which can be displayed on both N- and O-glycans on
cell surface glycoconjugates. Although first identified in
macrophages, galectin-3 (also called ‘Mac-2, εBP,
CBP35 or L-29’) has been found to be widely distributed
in several tissues and developmental stages where,
depending on its extracellular or intracellular
localization, it can display a broad diversity of biological
functions including immunomodulation, host-pathogen
interactions, embryogenesis, angiogenesis, cell
migration, wound healing and apoptosis. In spite of the
existence of several reviews describing the
multifunctional properties of galectin-3, an integrated
view of the regulated expression of this glycan-binding
protein in different normal tissues is lacking. Here we
attempt to summarize and integrate available
information on galectin-3 distribution in normal
haematopoietic and non-haematopoietic tissues, mainly
in adulthood, with only a brief reference to its expression
during embryonic stages. In addition, given the
multiplicity of biological roles attributed to this protein,
a brief description of galectin-3 functions is also
included. Understanding how galectin-3 is regulated in
normal tissues will contribute to a rational design of
approaches aimed at modulating galectin-3 expression
and subcellular localization for experimental and
therapeutic purposes.
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