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P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas

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Pcadherin expression predicts clinical.pdf(3.13 MB)
Date
2004
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Authors
Lo Muzio, L. ; Pannone, G. ; Mignogna, M.D. ; Staibano, S. ; Mariggiò, M.A. ; Rubini, C. ; Procaccini, M. ; Dolcl, M. ; Bufo, P. ; De Rosa, G. ; Piattelli, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
P-cadherin, a transmembrane molecule similar to E-cadherin involved in the cell-cell adhesion, and catenins form complexes between its cytoplasmic domain and the cytoskeleton. Five cell lines, 108 specimens of oral squamous cell carcinomas (OSCC), 9 metastasis and 10 of normal oral mucosa were examined to evaluate P-cadherin expression and cellular localization by immunohistochemistry and westernblotting. In normal oral mucosa there was a membranous expression only in basal and parabasal layers. 91 cases (84%) showed membranous/cytoplasmic positivity, whereas 17 cases (16%) were negative. In particular, while well-differentiated carcinomas showed P-cadherin upregulation, the protein was homogeneously hypo- or unexpressed in low-differentiated carcinomas. There was a statistically significant correlation between P-cadherin expression and tumour grading: G3 tumours had a lower score than G1-G2 tumours (P<0.05). When analysed for prognostic significance, patients with no P-cadherin expression (score 0) had poorer overall and diseases-free survival rates than the P-cadherin-expressing group (score 1) (P=0.0463 and P=0.0471, respectively). Western blotting analysis of cell lines and tissue samples confirmed immunohistochemical findings. When cell staining pattern of positive cases was examined, 52 cases showed a prevalent membranous pattern, while 39 had a prevalent cytoplasmic pattern. Cases with prevalent cytoplasmic staining showed high rates of lymph node metastases (P>0.05), and regional relapse (P <0.05) and poorer survival rates than the group with prevalent membranous expression (P<0.0001). An absent Pcadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma.
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Head and neck , P-cadherin
Citation
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http://hdl.handle.net/10201/21626
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Histology and histopathology Vol.19, nº 4 (2004)
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