Publication: Cytoglobin expression of rectal subepithelial myofibroblasts: Significant alterations of cytoglobin+ stromal cells in long-standing ulcerative colitis
Authors
Okayasu, Isao ; Mikami, Tetuo ; Yoshida, Tsutomu ; Hana, Kiyomi ; Yokozawa, Yokozawa ; Sada, Miwa ; Fujiwara, Mutsunori ; Kawada, Norifumi
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Publisher
F. Hernández y Juan F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cytoglobin/stellate cell activation-associated
protein (Cygb/STAP), a hemoprotein, functions as part
of an O2 reservoir with protective effects against
oxidative stress in hepatic stellate cells. Heterogeneous
expression of the neural cell adhesion molecule
(NCAM)+ and/or α-smooth muscle actin (αSMA)+ has
been noted in subepithelial myofibroblasts and
interstitial cells of the same lineage in the colorectum.
We have demonstrated that early genomic instability of
both epithelial and stromal cells in ulcerative colitis
(UC) is important for colorectal tumorigenesis, as well
as for mucosal remodeling. To further clarify possible
roles of stromal cells in mucosal remodeling and tumor
development in UC, we here focused on Cygb
expression of subepithelial myofibroblasts and
interstitial cells, as well as αSMA and HSP47.
Noncancerous mucosa of resected rectae from UC
patients with or without colorectal neoplasia (14 and 20
cases, respectively) and of sporadic rectal cancer cases
(16) was analyzed immunohistochemically, as well as by
immuno-fluorescence and electron microscopy. The
results, heterogeneous phenotypes of Cygb+, αSMA+
and HSP47+ subepithelial myofibroblasts and interstitial
cells, corresponding to rectal stellate cells, were
demonstrated. A decrease of Cygb+ subepithelial
myofibroblasts and an increase of αSMA+ interstitial
cells were significant in UC, as compared to normal
rectal mucosa. Furthermore, a decrease of Cygb+
subepithelial myofibroblasts, correlating with αSMA+
and HSP47+ cells, was significant in long-standing UC with neoplasia. In conclusion, there are heterogeneous
phenotypes of Cygb+, αSMA+ and HSP47+ subepithelial
myofibroblasts and interstitial cells in the rectal mucosa.
Mucosal remodeling with alterations of Cygb+ and/or
αSMA+/HSP47+ stromal cells might have some relation
to UC-associated tumorigenesis.
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