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Golgi apparatus localization of ZNT7 in the mouse cerebellum

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dc.contributor.authorGao, Hui-Linges
dc.contributor.authorFeng, Wan-Yues
dc.contributor.authorLi, Xiao-Ling
dc.contributor.authorXu, He
dc.contributor.authorHuang, Liping
dc.contributor.authorWang, Zhan-You
dc.date.accessioned2013-09-24T11:35:12Z
dc.date.available2013-09-24T11:35:12Z
dc.date.issued2009
dc.description.abstractWe have recently reported that four members of the zinc transporter (ZNT) family, ZNT1, ZNT3, ZNT4, and ZNT6, are abundantly expressed in the mouse cerebellum. In the present study, we reported that ZNT7 was present throughout the cerebellar cortex. ZNT7 immunoreactivity was predominately present in the somas and primary dendrites of the Purkinje cells. ZNT7 was also present in the Bergmann glial cell bodies as well as their radial processes, which extended into the molecular cell layer. Confocal immunofluorescence results demonstrated that the expression of ZNT7 overlapped with that of TGN38 in the somas of the Purkinje cells and granule cells. Immuno-electron microscopic study showed that ZNT7 was localized to the membrane of the Golgi apparatus in the somas of the Purkinje cells, Bergmann glial cells, and granule cells. Western blot analysis demonstrated that a considerable amount of ZNT7 was expressed in the cerebellum. These findings suggest a significant role of ZNT7 in zinc homeostasis in the mouse cerebellum.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36024
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCerebellumes
dc.subjectMousees
dc.subject.other615 - Farmacología. Terapéutica. Toxicología. Radiologíaes
dc.titleGolgi apparatus localization of ZNT7 in the mouse cerebellumes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº5 (2009)