Publication: Physiopathologic dynamics
of vesicle traffic in astrocytes
Authors
Potokar, Maja ; Stenovec, Matjaž ; Kreft, Marko ; Gabrijel, Mateja ; Zorec, Robert
item.page.secondaryauthor
item.page.director
Publisher
Murcia: F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
. The view of how astrocytes, a type of glial
cells, contribute to the functioning of the central nervous
system (CNS) has changed greatly in the last decade.
Although glial cells outnumber neurons in the
mammalian brain, it was considered for over a century
that they played a subservient role to neurons. This view
changed. Functions thought to be exclusively present in
neurons, i.e. excitability mediated release of chemical
messengers, has also been demonstrated in astrocytes. In
this process, following an increase in cytosolic calcium
activity, membrane bound vesicles, storing chemical
messengers (gliotransmitters), fuse with the plasma
membrane, a process known as exocytosis, permitting
the exit of vesicle cargo into the extracellular space.
Vesicles are delivered to and are removed from the site
of exocytosis by an amazingly complex set of processes
that we have only started to learn about recently. In this
paper we review vesicle traffic, which is subject to
physiological regulation and may be changed under
pathological conditions.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.