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Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

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dc.contributor.authorTsubura, A.es
dc.contributor.authorYoshizawa, K.es
dc.contributor.authorKuwata, M.
dc.contributor.authorUehara, N.
dc.date.accessioned2015-09-29T07:17:45Z
dc.date.available2015-09-29T07:17:45Z
dc.date.issued2010
dc.description.abstractRetinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46319
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRetinitis pigmentosaes
dc.subjectApoptosises
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleAnimal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trialses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº7 (2010)