Publication: Bone marrow stromal cells for spinal cord repair, A challenge for contemporary neurobiology
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Date
2009
Authors
Vaquero, J. ; Zurita, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In the last years, it has been reported that
bone marrow stromal cells (BMSC) are able to
differentiate towards a neuronal phenotype, in vitro as
well as in vivo, and consequently, the possible use of
these cells for the treatment of neurological diseases has
acquired enormous importance. The objective of this
review is to discuss the experimental findings that
suggested the utility of BMSC for the treatment of
paraplegia, and the possibilities of its clinical application
in patients. For this reason, we revise our previous
experimental findings about neuronal transdifferentiation
of BMSC, and the utility of local BMSC transplantation
in an experimental model of chronic paraplegia. Our
current experience supports that a neural
transdifferentiation of BMSC is possible after these
mesenchymal stem cells are transplanted into injured
spinal cord tissue. Furthermore, this cell therapy
achieves a clear functional improvement of paraplegic
animals, together with morphological evidence of spinal
cord regeneration. Although at present our efforts should
be guided to obtain a better knowledge of the
mechanisms of nervous regeneration induced by bonemarrow
derived stem cells, it is obvious that cell therapy
for nervous system repair is beginning, and BMSC
transplantation offers new hope for the treatment of
traumatic paraplegia in humans.
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