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Expression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complex

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dc.contributor.authorMedina, Loreta
dc.contributor.authorGonzález, Gertrudis
dc.contributor.authorCastro, Fernando de
dc.contributor.authorRubenstein, John L.R.
dc.contributor.authorPuelles, Luis
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:31:33Z
dc.date.available2024-07-12T08:31:33Z
dc.date.issued2004-07-05
dc.description© 2004 Wiley-Liss, Inc. This document is the Published version of a Published Work that appeared in final form in The Journal of Comparative Neurology (JCN). To access the final edited and published work see https://doi.org/10.1002/cne.20141
dc.description.abstractWe studied the lateral and ventral pallial divisions of the claustroamygdaloid complex by means of analysis of expression patterns of the developmental regulatory genes Tbr1, Dbx1, Neurogenin 2, Emx1, Cadherin 8, and Semaphorin 5A in mouse developing telencephalon, from embryonic day 12.5 until birth. Our results indicate that these genes help to distinguish distinct lateral and ventral pallial histogenetic divisions in the embryonic telencephalon. Tbr1 is broadly expressed in both lateral and ventral pallial histogenetic divisions (the lateroventral migratory stream plus the mantle) during early and intermediate embryonic development; its signal becomes weak in parts of the mantle during late embryonic development. Dbx1 is strongly and specifically expressed in progenitor cells (ventricular zone) of the ventral pallium during early embryonic development, but there is no signal of this gene in the rest of the pallium nor the subpallium. Neurogenin 2 and Semaphorin 5A are both expressed in a ventral subdivision of the lateroventral migratory stream (called by us the ventral migratory stream). Further, specific nuclei of the claustral complex and pallial amygdala show strong expression of Neurogenin 2 and/or Semaphorin 5A, including the ventromedial claustrum and endopiriform nuclei, the lateral and basomedial amygdalar nuclei, the anterior and posteromedial cortical amygdalar areas, plus the amygdalo-hippocampal area. We interpret these nuclei or areas of the claustroamygdaloid complex as possible derivatives of the ventral pallium. In contrast, during embryonic development the dorsolateral claustrum, the basolateral amygdalar nucleus, and the posterolateral cortical amygdalar area do not express or show weak expression of Neurogenin 2 or Semaphorin 5A, but express selectively and strongly Cadherin 8 plus Emx1, and may be derivatives of the lateral pallium. The lateral pallial and ventral pallial divisions of the claustroamygdaloid complex appear to have some different sets of connections, although this requires further investigation.es
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dc.identifier.citationThe Journal of Comparative Neurology, 2004, Vol. 474, Issue 4, pp. 504-523
dc.identifier.doihttps://doi.org/10.1002/cne.20141
dc.identifier.issnPrint: 0021-9967
dc.identifier.issnElectronic: 1096-9861
dc.identifier.urihttp://hdl.handle.net/10201/143052
dc.languageenges
dc.publisherWiley
dc.relationGrant sponsor: Spanish Ministry of Science and Technology CICYTFEDER; Grant number: PBI2001-3688 (L.P.); Grant number: BFI2000-1359- C02-02 (L.M.); Grant sponsor: Se´neca Foundation; Grant number: PI-64/ 00862/FS/01 (L.P.); Grant number: PB/25/FS/99 (L.M.); Grant number: PB/ 50/FS/02 (L.M.); Grant sponsor: Spanish Ministry of Health-Institute Carlos III; Grant number: FIS 01/0057-02 (L.M.); Grant number: PI020768 (F.deC.); Red CIEN C03/06-Nodo 318 (L.P., L.M.); Grant sponsor: Nina Ireland; Grant sponsor: National Institute of Neurological Disorders and Stroke; Grant number: R01 NS34661-01A1 (J.L.R.R.); Fellowship sponsor: Spanish Ministry of Science and Technology; Fellowship number: FP2000-5943 (I.L.).es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/cne.20141
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectClaustrum
dc.subjectEndopiriform nucleus
dc.subjectPallial amygdala
dc.subjectBasolateral amygdala
dc.subjectDevelopmental regulatory genes
dc.titleExpression of Dbx1, Neurogenin 2, Semaphorin 5A, Cadherin 8, and Emx1 distinguish ventral and lateral pallial histogenetic divisions in the developing mouse claustroamygdaloid complexes
dc.typeinfo:eu-repo/semantics/articlees
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