Publication: MUC1 (EMA) expressing plasma cells in bone marrow infiltrated by plasma cell myeloma
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Date
2007
Authors
Baldus, S.E. ; Palmen, C. ; Thiele, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
MUC1 (also called: epithelial membrane
antigen, EMA) represents a mucin molecule strongly
expressed in various epithelia and epithelial neoplasms.
Its expression correlates with clinical and pathological
factors as well as prognosis in some tumor types.
Additionally, MUC1 was detected in normal
haematopoietic cell lines and neoplasms, especially
subgroups of human lymphomas including plasma cell
myeloma. Therefore, the expression of MUC1 in
trephine biopsies exhibiting infiltrates of plasma cell
myeloma were investigated immunohistochemically. An
immunoreactivity of two monoclonal antibodies (EMA
and HMFG-2) was observed in about 50% of the cases.
In cases exhibiting a so-called packed marrow, EMA
immunoreactivity was reduced. However, MUC1
positivity did not correlate with the cytologic grade of
differentiation, the fibre content of the marrow, or
survival probability of the patients. However, its strong
expression in a certain percentage of cases of plasma cell
myeloma may be of therapeutic impact, since new
therapeutic strategies include the enrichment of MUC1-
specific T cells or MUC1 vaccination.
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