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Mural Endocarditis: The GAMES Registry Series and Review of the Literature

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dc.contributor.authorGutiérrez-Villanueva, Andrea
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorDelgado-Montero, Antonia
dc.contributor.authorOlmedo-Samperio, María
dc.contributor.authorAlarcón, Arístides de
dc.contributor.authorGutiérrez-Carretero, Encarnación
dc.contributor.authorZarauza, Jesús
dc.contributor.authorGarcía i Pares, Delia
dc.contributor.authorGoenaga, Miguel Ángel
dc.contributor.authorOjeda-Burgos, Guillermo
dc.contributor.authorGoikoetxea-Agirre, Ane Josune
dc.contributor.authorReguera-Iglesias, José Mª
dc.contributor.authorRamos, Antonio
dc.contributor.authorFernández-Cruz, Ana
dc.contributor.authorGrupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES)S)
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-28T11:54:22Z
dc.date.available2024-06-28T11:54:22Z
dc.date.issued2021-07-26
dc.description© 2021 The Author(s). This manuscript version is made available under the CC-BY-NC 4.0 license http://creativecommons.org/licenses/by-nc/4.0/. This document is the Acceptedversion of a Published Work that appeared in final form in Infectious Diseases and Therapy. To access the final edited and published work see https://doi.org/10.1007/s40121-021-00490-yes
dc.description.abstractIntroduction: Mural infective endocarditis (MIE) is a rare type of endovascular infection. We present a comprehensive series of patients with mural endocarditis. Methods: Patients with infectious endocarditis (IE) from 35 Spanish hospitals were prospectively included in the GAMES registry between 2008 and 2017. MIEs were compared to non-MIEs. We also performed a literature search for cases of MIE published between 1979 and 2019 and compared them to the GAMEs series. Results: Twenty-seven MIEs out of 3676 IEs were included. When compared to valvular IE (VIE) or device associated IE (DIE), patients with MIE were younger (median age 59 years, p \ 0.01). Transplantation (18.5% versus 1.6% VIE and 2% DIE, p \ 0.01), hemodialysis (18.5% versus 4.3% VIE and 4.4% DIE, p = 0.006), catheter source (59.3% versus 9.7% VIE and 8.8% DIE, p \ 0.01) and Candida etiology (22.2% versus 2% DIE and 1.2% VIE, p \ 0.01) were more common in MIE, whereas the Charlson Index was lower (4 versus 5 in non- MIE, p = 0.006). Mortality was similar.MIE from the literature shared many characteristics with MIE from GAMES, although patients were younger (45 years vs. 56 years, p \ 0.001), the Charlson Index was lower (1.3 vs. 4.3, p = 0.0001), catheter source was less common (13.9% vs. 59.3%) and there were more IVDUs (25% vs. 3.7%). S. aureus was the most frequent microorganism (50%, p = 0.035). Systemic complications were more common but mortality was similar. Conclusion: MIE is a rare entity. It is often a complication of catheter use, particularly in immunocompromised and hemodialysis patients. Fungal etiology is common. Mortality is similar to other IEs.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.citationInfect Dis Ther. 2021, 10(4): 2749 - 2764
dc.identifier.doihttps://doi.org/10.1007/s40121-021-00490-y
dc.identifier.issnPrint: 2193-8229
dc.identifier.issnElectronic: 2193-6382
dc.identifier.urihttp://hdl.handle.net/10201/142758
dc.languageenges
dc.publisherSpringeres
dc.relationSin financiación externa a la Universidades
dc.relation.ispartofThis manuscript is based on work that has been previously presented as an oral communication at the VIIIth Congress of SEICAV (Spanish Society of Cardiovascular Infections) in Madrid, September 2019.es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40121-021-00490-yes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectEndocarditises
dc.subjectMurales
dc.subjectNon-valvular endocarditises
dc.titleMural Endocarditis: The GAMES Registry Series and Review of the Literaturees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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