Recent Advances and Future Directions in the Understanding of Mucormycosis

Garre Mula, Victoriano

Publication:
Recent Advances and Future Directions in the Understanding of Mucormycosis

dc.contributor.author	Garre Mula, Victoriano
dc.contributor.department	Genética y Microbiología
dc.date.accessioned	2022-04-29T22:10:30Z
dc.date.available	2022-04-29T22:10:30Z
dc.date.issued	2022-02-24
dc.description	©<2022>. This manuscript version is made available under the CC-BY4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Frontiers in Cellular and Infection Microbiology. To access the final edited and published work see doi: 10.3389/fcimb.2022.850581
dc.description.abstract	Mucormycosis is an emerging infection caused by fungi of the order Mucorales that has recently gained public relevance due to the high incidence among COVID-19 patients in some countries. The reduced knowledge about Mucorales pathogenesis is due, in large part, to the historically low interest for these fungi fostered by their reluctance to be genetically manipulated. The recent introduction of more tractable genetic models together with an increasing number of available whole genome sequences and genomic analyses have improved our understanding of Mucorales biology and mucormycosis in the last ten years. This review summarizes the most significant advances in diagnosis, understanding of the innate and acquired resistance to antifungals, identification of new virulence factors and molecular mechanisms involved in the infection. The increased awareness about the disease and the recent successful genetic manipulation of previous intractable fungal models using CRISPR-Cas9 technology are expected to fuel the characterization of Mucorales pathogenesis, facilitating the development of effective treatments to fight this deadly infection.
dc.format	application/pdf	es
dc.identifier.citation	Frontiers in cellular and infection microbiology, vol.12,
dc.identifier.doi	doi: 10.3389/fcimb.2022.850581
dc.identifier.issn	2235-2988
dc.identifier.uri	http://hdl.handle.net/10201/119383
dc.language	eng	es
dc.relation.isreferencedby	ED_IDENTRADA=1041
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.title	Recent Advances and Future Directions in the Understanding of Mucormycosis	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es