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Iron bioavailability of four iron sources used to fortify infant cereals, using anemic weaning pigs as a model

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dc.contributor.authorCaballero-Valcarcel, A
dc.contributor.authorMartinez-Gracia, C
dc.contributor.authorMartinez-Miro, S
dc.contributor.authorMadrid-Sanchez, J
dc.contributor.authorGonzalez-Bermudez, CA
dc.contributor.authorDomenech-Asensi, G
dc.contributor.authorLopez-Nicolas, R
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.departmentEnfermería
dc.date.accessioned2024-02-06T12:58:08Z
dc.date.available2024-02-06T12:58:08Z
dc.date.created2018-08
dc.description©2018. This document is the Accepted version of a Published Work that appeared in final form in European Journal of Nutrition. To access the final edited and published work see https://doi.org/10.1007/s00394-018-1742-x
dc.description.abstractPurpose Iron (Fe) deficiency anemia in young children is a global health concern which can be reduced by Fe fortification of foods. Cereal is often one of the first foods given to infants, providing adequate quantities of Fe during weaning. In this work, we have compared iron bioavailability and iron status of four iron sources used to fortify infant cereals, employing piglets as an animal model. Method The study was conducted on 36 piglets, 30 of them with induced anemia. From day 28 of life, the weaned piglets were fed with four experimental diets (n=6) each fortified with 120mg Fe/kg by ferrous sulfate heptahydrate (FSH), electrolytic iron (EI), ferrous fumarate (FF), or micronized dispersible ferric pyrophosphate (MDFP) for another 21days. In addition, one group of six anemic piglets fed with the basal diet with no iron added (Control-) and a Control+ group of non-anemic piglets (n=6) were also studied. Blood indicators of iron status were measured after depletion and during the repletion period. The Fe content in organs, hemoglobin regeneration efficiency, and relative bioavailability (RBV) was also determined. Results The Fe salts adequately treated anemia in the piglets, allowing the animals to recover from the anemic state, although EI was less efficient with regard to replenishing Fe stores giving lower concentrations of plasma ferritin and iron in the spleen, liver, lung, and kidney. In addition, the RBV of EI was 88.27% with respect to the reference iron salt (FSH). Conclusions Ferrous fumarate and MDFP were equally as bioavailable as the reference salt, and were used significantly better than EI in piglets. These results contribute to extend the evidence-based results for recommending the most suitable fortificant for infant cereals.es
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dc.format.extent12es
dc.identifier.citationEuropean Journal of Nutrition, Volume 58, Issue 5, Page 1911-1922
dc.identifier.doihttps://doi.org/10.1007/s00394-018-1742-x
dc.identifier.issn1436-6207
dc.identifier.issn1436-6215
dc.identifier.urihttp://hdl.handle.net/10201/138757
dc.languageenges
dc.relationSupported by the Ministry of Science and Innovation of the Spanish Government (Secretaría de Estado de Investigación, Desarrollo e Innovación) (Project Ref. AGL2013-40617-R).es
dc.rightsAttribution-NonCommercial-NoDerivates 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectIron fortificationes
dc.subjectBioavailabilityes
dc.subjectIron statuses
dc.subjectWeaned pigletses
dc.subjectIron saltses
dc.subject.otherCDU::5 - Ciencias puras y naturaleses
dc.titleIron bioavailability of four iron sources used to fortify infant cereals, using anemic weaning pigs as a modeles
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication2d5dac0f-c6c6-485b-97bf-c679f4940e3d
relation.isAuthorOfPublication.latestForDiscovery2d5dac0f-c6c6-485b-97bf-c679f4940e3d
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