Publication: Alveolar bone of BBMl rats: a morphometric
and histochemical study
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Date
1989
Authors
Johnson, R. B. ; Carlson, E. C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study reported histochemical
changes in alveolar bone glycosaminoglycans (GAG)
(using Safranin 0 ) and in interdental bone height in
three groups of BB/W rats: diabetic, diabetes prone, and
diabetes resistant. Safranin O staining intensity
suggested that total GAG levels were highest in diabetic
bone (p<0.05 compared to diabetes resistant, p<0.005
compared to diabetes prone) but not significantly
different between diabetes prone and resistant groups.
Following chondroitinase AC and ABC digestion,
staining reactions suggested that the highest levels of
dermatan sulfate were in the diabetes resistant group
(p<0.001 compared to diabetic, p<0.001 compared to
diabetes prone) and the highest levels of chondroitin
sulfates were in the diabetes prone group (p<0.001).
Coincidently the mean height of diabetes prone
interdental septum was significantly less than that of
diabetes resistant or diabetic groups (p<0.05). The study
suggested that 1) diabetes and «prediabetes» produce
significant changes in levels of chondroitin 4, 6, and
dermatan sulfates within alveolar bone, 2) in
«prediabetic» animals, interdental bone loss occurs prior
to the onset of clinical symptoms and in the absence of
local irritating factors, the bone height appears to return
to normal levels, and 3) there may be a correlation
between alveolar bone height and relative levels of
dermatan sulfate.
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