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Influence and role of regulatory B cells in organ transplantation: the state of the art, prospects, and emerging insights

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dc.contributor.authorFernández-González, Marina
dc.contributor.authorLlorente, Santiago
dc.contributor.authorGalián, José Antonio
dc.contributor.authorBotella, Carmen
dc.contributor.authorGonzález-López, Rosana
dc.contributor.authorAlegría, María José
dc.contributor.authorHita, Alicia
dc.contributor.authorMoya-Quiles, María Rosa
dc.contributor.authorMartinez-Banaclocha, Helios
dc.contributor.authorMuro-Pérez, Manuel
dc.contributor.authorMuro, Javier
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.authorMuro, Manuel
dc.contributor.departmentCiencias Sociosanitarias
dc.contributor.otherFacultad de Química
dc.date.accessioned2026-01-22T09:57:20Z
dc.date.available2026-01-22T09:57:20Z
dc.date.copyright© 2025 by the authors
dc.date.issued2025-11-07
dc.description.abstractB cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppressive properties and which might contribute to allograft tolerance, within the B cell compartment in humans and mice. In this mini review, we summarize all the information available in the published reports about the role of regulatory B cells in solid organ transplantation.
dc.formatapplication/pdf
dc.format.extent16
dc.identifier.citationAntibodies 2025, 14, 95
dc.identifier.doihttps://doi.org/10.3390/antib14040095
dc.identifier.eissn2073-4468
dc.identifier.urihttp://hdl.handle.net/10201/190669
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by Virgen de la Arrixaca University Clinic Hospital and Biomedical Research Institute of Murcia (IMIB) (Murcia, Spain) within the framework of the PI19/01194 National Research Project funded by the Carlos III Health Institute (Madrid, Spain) and “Mutua Madrileña”Foundation project AP183152023.
dc.relation.publisherversionhttps://www.mdpi.com/2073-4468/14/4/95
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectRegulation of immune response
dc.subjectRegulatory B cells
dc.subjectTolerance
dc.subjectTransitional B cells
dc.subjectKidney transplant
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleInfluence and role of regulatory B cells in organ transplantation: the state of the art, prospects, and emerging insights
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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