Publication: Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review
Authors
Machado, Isidro ; Navarro, Samuel ; Llombart Bosch, Antonio
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
publication.page.editor
publication.page.department
DOI
DOI: 10.14670/HH-11-792
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Ewing-like sarcomas (ELS) are a
heterogenous group of tumors that frequently affect
pediatric and young adult patients. Accurate
classification and distinction from the Ewing sarcoma
family of tumor (ESFT) is decisive in patient
management. ELS share a significant morphologic,
immunohistochemical and clinical overlap with ESFT,
thus the differential diagnosis is challenging, especially
with atypical ESFT and tumors with unusual immunoprofiles or uncommon clinicoradiological findings. A
subset of ELS harboring the CIC-DUX4 or BCORCCNB3 fusions has been described recently. The
spectrum of ELS is now expanding, and additional gene
fusion partners besides DUX4 or CCNB3 have been
detected, and the terms CIC or BCOR-rearranged
sarcomas have recently been proposed. We review the
clinical, histological, phenotypic and molecular findings
of ESFT and these new emerging ELS.
publication.page.subject
Citation
Histology and Histopathology, Vol.31, nÂş11, (2016)
item.page.embargo
Ir a EstadĂsticas
Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/