Publication: Prevalence of colorectal neoplasms among patients with enterococcus faecalis endocarditis in the GAMES cohort (2008-2017)
Authors
Pericàs, Juan M. ; Ambrosioni, Juan ; Muñoz, Patricia ; Alarcón, Arístides de ; Kestler, Martha ; Mari-Hualde, Amaia ; Moreno, Asunción ; Goenaga, Miguel Á. ; Fariñas, M. Carmen ; Rodríguez-Álvarez, Regino ; Ojeda-Burgos, Guillermo ; Gálvez-Acebal, Juan ; Hidalgo-Tenorio, Carmen ; Noureddine, Mariam ; Miró, José M. ; García-Vázquez, Elisa ; GAMEs investigators
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.mayocp.2020.06.056
Electronic: 1942-5546
Electronic: 1942-5546
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info:eu-repo/semantics/article
Description
©2020 Mayo Foundation for Medical Education and Research. This document is the Published, version of a Published Work that appeared in final form in Mayo Clinic Proceedings. To access the final edited and published work see https://doi.org/10.1016/j.mayocp.2020.06.056
Abstract
Objective: To investigate the rate of colorectal neoplasms (CRNs) in patients who have Enterococcus faecalis infective endocarditis (EFIE) with available colonoscopies and to assess whether this is associated with the identification of a focus the infection.
Patients and Methods: Retrospective analysis of data from a prospective multicenter study involving 35 centers who are members of the Grupo de Apoyo para el Manejo de la Endocarditis en España [Support
Group for the Management of Infective Endocarditis in Spain] cohort. A specific set of queries regarding
information on colonoscopy and histopathology of colorectal diseases was sent to each participating
center. Four-hundred sixty-seven patients with EFIE were included from January 1, 2008, to December 31,
2017, from whom data on colonoscopy performance and results were available in 411 patients.
Results: One hundred forty-two (34.5%) patients had a colonoscopy close to the EFIE episode. The overall rate of colorectal diseases was 70.4% (100 of 142), whereas the prevalence of CRN (advanced adenomas and colorectal carcinoma) was 14.8% (21 of 142), with no significant differences between the group of EFIE of unknown focus and that with an identified focus.
Conclusion: Our study adds to prior evidence suggesting a much higher rate of CRN among patients with EFIE than in the general population of the same age and sex. In addition, our findings suggest that this phenomenon might take place both in EFIE with an unknown and an identified source of infection.
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Citation
Mayo Clin Proc. January 2021 96(1):132-146
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