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Angiopoietin-1Tie2 receptor signaling in vascular quiescence and angiogenesis

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dc.contributor.authorFukuhara, Shigetomoes
dc.contributor.authorSako, Keisukees
dc.contributor.authorNoda, Kazuomi
dc.contributor.authorZhang, Jianghui
dc.contributor.authorMinami, Masayoshi
dc.contributor.authorMochizuki , Naoki
dc.date.accessioned2015-01-20T12:06:50Z
dc.date.available2015-01-20T12:06:50Z
dc.date.issued2010
dc.description.abstractAngiopoietin (Ang) 1 is a ligand forendothelium-specific receptor tyrosine kinase Tie-2. Inadult vasculature, Ang1/Tie2 signaling is thought toregulate both maintenance of vascular quiescence andpromotion of angiogenesis. However, it has beenunknown how Tie2 signal regulates these distinctbiological functions. Recently, we and Alitalo’s grouphave clarified that Ang1 assembles distinct Tie2signaling complexes in either presence or absence ofendothelial cell-cell adhesions. Ang1 induces trans-association of Tie2 at cell-cell contacts, whereas Tie2 isanchored to the extracellular matrix (ECM) by Ang1 atthe cell-substratum interface. Trans-associated Tie2 andECM-anchored Tie2 activate distinct signalingpathways. In this review, we discuss how Ang1/Tie2signal regulates both maintenance of vascular quiescenceand promotion of angiogenesis, especially focusing onthe roles of trans-associated Tie2 and ECM-anchoredTie2en_EN
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42589
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAngiogenesises
dc.subjectQuiescencees
dc.subject.other61 - Medicinaes
dc.titleAngiopoietin-1Tie2 receptor signaling in vascular quiescence and angiogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº3 (2010)