Publication: Lysosomal glycolipid storage in the renal tubular epithelium in mastomys (Praomys coucha)
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Date
1996
Authors
Fujimura, H. ; Ogura, A. ; Asano, T. ; Noguchi, Y. ; Mochida, K. ; Takimoto, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The renal proximal tubular epithelium of
MCC strain of mastomys (Praomys coucha) exhibited a
number of cytoplasmic vacuoles after conventional
paraffin-embedding procedures. These vacuoles were
strongly PAS-positive in cryostat sections. Ultrastructurally,
they were double membrane-bound
structures filled with myelin figures and acid
phosphatase-positive electron-dense matrix. Immunofluorescent
microscopy revealed that these structures
contained GM2 ganglioside. Other tissues or organs
were histologically normal. Mating experiments
indicated that the ganglioside storage in MCC mastomys
is inherited as an autosomal recessive trait.
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