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Evaluation of the antimicrobial potential of digested and undigested carob phenolic extracts: Impact on selected gut microbiota

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dc.contributor.authorChaalal, M.
dc.contributor.authorYdjedd, S.
dc.contributor.authorChemache, L.
dc.contributor.authorLópez Nicolás, Rubén
dc.contributor.authorSánchez Moya, Teresa
dc.contributor.authorFrontela Saseta, María del Carmen
dc.contributor.authorRos Berruezo, Gaspar
dc.contributor.authorKati, D.E.
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.date.accessioned2026-01-12T08:44:04Z
dc.date.available2026-01-12T08:44:04Z
dc.date.copyright© 2023 The Author(s)
dc.date.issued2023-10-19
dc.description.abstractCarob pulp is a natural source of polyphenols, which have been shown to possess health benefits. These compounds play a crucial role in initiating, shaping, and modulating the gut microbiota. The objective of this study was to evaluate the impact of carob pulp phenolic extracts on nine specific groups of human gut microbiota before and after in vitro gastrointestinal digestion. The effects of pure gallic and coumaric acids were also tested. The results showed that the treated phenolic compounds exhibited inhibitory effects on the growth of most pathogenic bacteria. Gallic acid, in particular, demonstrated the most potent antimicrobial effect on Listeria monocytogenes, reducing its growth to below 5%. Staphylococcus aureus and Escherichia coli showed a growth reduction of up to 10%. Furthermore, both phenolic acids, before and after digestion, led to a slight reduction in E. coli O157:H7 numbers. Probiotic bacteria experienced minimal decrease following exposure to phenolic extracts. However, the growth of Lactobacillus casei ssp. rhamnosus was significantly inhibited by almost 50%. Interestingly, the in vitro digestion process exhibited a stronger antibacterial effect against pathogenic bacteria compared to probiotic bacteria. These results highlight the potential of carob phenolic extracts in modulating the intestinal microbiota, thereby offering interesting prospects for the development of diet-based health strategies.
dc.formatapplication/pdf
dc.format.extent11
dc.identifier.citationActa Alimentaria 52 (2023) 4, 612–622
dc.identifier.doihttps://doi.org/10.1556/066.2023.00172
dc.identifier.eissn1588-2535
dc.identifier.issn0139-3006
dc.identifier.urihttp://hdl.handle.net/10201/185569
dc.languageeng
dc.publisherAKJournals
dc.relationThe present research was performed under the financial support of the Algerian Ministry of Higher Education and Scientific Research in collaboration with the Human Nutrition and Food Science Research Group (NUTBRO) of the University of Murcia (Spain) (E098-02) and Ministerio de Economıa y Competitividad (Spain) through the Project ́AGL2016-78125-R.
dc.relation.publisherversionhttps://akjournals.com/view/journals/066/52/4/article-p612.xml
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectCarob pulp
dc.subjectPhenolic extracts
dc.subjectIn vitro digestion
dc.subjectIntestinal microbiota
dc.subjectAntimicrobial potential
dc.subject.odsObjetivo 3: Salud
dc.titleEvaluation of the antimicrobial potential of digested and undigested carob phenolic extracts: Impact on selected gut microbiota
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
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