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E-cadherin in oral SCC: An analysis of the confusing literature and new insights related to its immunohistochemical expression

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dc.contributor.authorVered, Marilena
dc.contributor.authorAllon, Irit
dc.contributor.authorBuchner, Amos
dc.contributor.authorDayan, Dan
dc.date.accessioned2017-03-08T18:24:03Z
dc.date.available2017-03-08T18:24:03Z
dc.date.issued2012
dc.description.abstractE-cadherin plays a crucial structural role in cell-cell contacts in epithelial tissues, and a functional role in signaling pathways that regulate cell proliferation, differentiation, and survival. Reduced immunoexpression of E-cadherin adhesions is largely considered as being equivalent to defective functionality and malignancy, and has been used as a prognostic parameter. A critical analysis of studies on E-cadherin immunoexpression in oral carcinomas revealed a wide range of both technical and interpretational aspects. This paper highlights biological characteristics of E-cadherin with respect to its expression in normal and neoplastic epithelial cells and to its interrelations with the tumor microenvironment that can have an impact on immunohistochemical results and their application in the clinical settinges
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and histopathology, Vol. 27, nº 2 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/52385
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectOral canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleE-cadherin in oral SCC: An analysis of the confusing literature and new insights related to its immunohistochemical expressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 2 (2012)