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High-grade renal cell carcinoma with emperipolesis: Clinicopathological, immunohistochemical and molecular-genetic analysis of 14 cases

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dc.contributor.authorRotterova, Pavla
dc.contributor.authorMartinek, Petr
dc.contributor.authorAlaghehbandan, Reza
dc.contributor.authorProchazkova, Kristyna
dc.contributor.authorDamjanov, Iván
dc.contributor.authorRogala, Joanna
dc.contributor.authorSuster, Saul
dc.contributor.authorPerez Montiel, Delia
dc.contributor.authorAlvarado Cabrero, Isabel
dc.contributor.authorSperga, Maris
dc.contributor.authorŠvajdler, Marián
dc.contributor.authorMichalova, Kvetoslava
dc.contributor.authorPivovarcikova, Kristyna
dc.contributor.authorDaum, Ondrej
dc.contributor.authorHora, Milan
dc.contributor.authorDusek, Martin
dc.contributor.authorOndic, Ondrej
dc.contributor.authorStehlikova, Adela
dc.contributor.authorMichal, Michal
dc.contributor.authorHes, Ondrej
dc.date.accessioned2022-04-05T08:57:22Z
dc.date.available2022-04-05T08:57:22Z
dc.date.issued2018
dc.description.abstractEmperipolesis has recently been described as a constant feature of “biphasic squamoid” papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC showing emperipolesis were retrieved from our registry. Microscopic examination of filed slides was supplemented with immunohistochemical and molecular-genetic analyses using paraffin embedded tissue. 12 of 14 patients were males with a mean age of 58.6 years (range 41-72 years). Tumor size ranged from 6-16.5 cm (mean of 8.8 cm). Follow up data were available for 8/14 patients (range 0.5-10 years). Metastases were documented in 6 cases. All tumors showed solid-alveolar growth patterns with focal pseudopapillary features, and were composed of large cells with bizarre nuclei and eosinophilic rhabdoid-like cytoplasm. Emperipolesis was a constant and prominent feature in large bizarre cells. All cases were positive for OSCAR, CANH 9, vimentin, cyclin D1, INI-1, and myoD1, while negative for melanocytic markers, CK 7, myoglobin, cathepsin K, and TFE3. VHL gene abnormalities were found in 6/9 analyzable cases, of which 2 demonstrated polysomy of chromosomes 7, 17. Emperipolesis is a rare histomorphologic feature which can be seen not only in BPRCCs but also in highgrade CCRCCs. All RCC cases with prominent emperipolesis fulfilled both morphologic and immunohistochemical diagnostic criteria of high-grade CCRCC. The majority of patients with available follow up information developed metastases.es
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dc.format.extent11es
dc.identifier.citationHistology and Histopathology, Vol.33, nº3, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-925
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118730
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKidneyes
dc.subjectClear cell renal cell carcinomaes
dc.subjectHigh-gradees
dc.subjectEmperipolesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleHigh-grade renal cell carcinoma with emperipolesis: Clinicopathological, immunohistochemical and molecular-genetic analysis of 14 caseses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nº3 (2018)