The effect of Glioblastoma on Pericytes

Molina Gallego, María Luisa; Valdor Alonso, Rut

Publication:
The effect of Glioblastoma on Pericytes

dc.contributor.author	Molina Gallego, María Luisa
dc.contributor.author	Valdor Alonso, Rut
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2024-07-04T11:06:05Z
dc.date.available	2024-07-04T11:06:05Z
dc.date.issued	2020-10-29
dc.description.abstract	Purpose of the Review: Intratumoral pericytes (PC) do not share the same tumor niche as peritumoral PC. Furthermore, glioblastoma multiforme (GB) cells do not seem to affect them equally. Therefore, for a better understanding of the effects of GB on PC, in this chapter, we will classify them according to whether they are intratumoral or peritumoral PC, focusing mainly on peritumoral effects, which seem to have better future prospects for finding effective therapies in GB cancer. Recent Findings: Recently, it has been shown that PC could be the main target of the tumor infiltration front and have a fundamental role in the proliferation, expansion, and survival of the tumor, as well as in the regulation of anti-tumor immune responses. Modulation of the immune function of PC through molecular mechanisms such as chaperone-mediated autophagy (CMA) seems to be essential to prevent an immunosuppressive microenviroment that facilitates tumor growth. Summary: GB is the most frequent and aggressive brain tumor. In the last years, PC have been gaining special attention due to their role in GB progression. GB cells infiltrate away from the tumor core more often and faster when they are associated with perivascular cells. However, to find targeted therapies against PC to promote their brain defense function and improve anti-tumor immune responses requires a better understanding of the heterogeneity, markers, and distribution of PC at origin.	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Current Tissue Microenvironment Reports. Volume 1, pages 171–181, (2020)
dc.identifier.doi	https://doi.org/10.1007/s43152-020-00016-7
dc.identifier.issn	2662-4079
dc.identifier.uri	http://hdl.handle.net/10201/142853
dc.language	eng	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/closedAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Pericytes	es
dc.subject	Glioblastoma	es
dc.subject	Peritumoral	es
dc.subject	Intratumoral	es
dc.subject	Immune evasion	es
dc.title	The effect of Glioblastoma on Pericytes	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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