Publication: Cellular distribution of growth
hormone-releasing hormone receptor in human
reproductive system and breast and prostate cancers
Authors
Gallego, R. ; Pintos, E. ; Garcia-Caballero, Tomas ; Raghay, K. ; Boulanger, L. ; Beiras, Andres ; Gaudreau, P. ; Morel, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Growth hormone releasing hormone receptor
(GHRH-R) mRNA and protein was first localized to the
anterior pituitary gland, consequent with the action of its
ligand on GH synthesis and release. Subsequent studies
found GHRH-R also expressed in the hypothalamus and
in systemic tissues including those of the reproductive
system. In the present work, we studied the distribution
of GHRH-R in human reproductive system of males and
females by immunohistochemical method. GHRH-R
immunostaining was localized in male reproductive
system: Leydig cells, Sertoli and basal germ cells of the
seminiferous tubules and prostate secretory cells.
GHRH-R immunostaining was also demonstrated in the
ovary: oocytes, follicular cells, granulosa, thecal and
corpus luteum cells. Endometrial glands, placenta and
normal mammary glands also showed GHRH-R
immunostaining. Our results demonstrate the
localization of GHRH-R in the reproductive system,
which may mediate the direct action of GHRH in these
tissues. Moreover, GHRH-R was demonstrated in
prostate and breast carcinomas, opening a variety of
possibilities for the use of GHRH antagonists in the
treatment of prostatic and mammary tumors.
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