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Systematic review on the metabolic interest of glucosinolates and their bioactive derivatives for human health

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dc.contributor.authorNúñez Gómez, Vanesa
dc.contributor.authorCosta-Pérez, Antonio
dc.contributor.authorBaenas Navarro, Nieves
dc.contributor.authorDi Pede, Giuseppe
dc.contributor.authorAchour, Mariem
dc.contributor.authorManach, Claudine
dc.contributor.authorMena, Pedro
dc.contributor.authorDel Rio, Daniele
dc.contributor.authorGarcía-Viguera, Cristina
dc.contributor.authorMoreno, Diego A.
dc.contributor.authorDomínguez-Perles, Raúl
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.contributor.otherFacultad de Veterinaria
dc.date.accessioned2026-02-19T11:20:42Z
dc.date.available2026-02-19T11:20:42Z
dc.date.copyright© 2023 by the authors
dc.date.issued2023-03-15
dc.description.abstractIn the last decade, most of the evidence on the clinical benefits of including cruciferous foods in the diet has been focused on the content of glucosinolates (GSL) and their corresponding isothiocyanates (ITC), and mercapturic acid pathway metabolites, based on their capacity to modulate clinical, biochemical, and molecular parameters. The present systematic review summarizes findings of human studies regarding the metabolism and bioavailability of GSL and ITC, providing a comprehensive analysis that will help guide future research studies and facilitate the consultation of the latest advances in this booming and less profusely researched area of GSL for food and health. The literature search was carried out in Scopus, PubMed and the Web of Science, under the criteria of including publications centered on human subjects and the use of Brassicaceae foods in different formulations (including extracts, beverages, and tablets), as significant sources of bioactive compounds, in different types of subjects, and against certain diseases. Twenty-eight human intervention studies met inclusion criteria, which were classified into three groups depending on the dietary source. This review summarizes recent studies that provided interesting contributions, but also uncovered the many potential venues for future research on the benefits of consuming cruciferous foods in our health and well-being. The research will continue to support the inclusion of GSL-rich foods and products for multiple preventive and active programs in nutrition and well-being.
dc.formatapplication/pdf
dc.format.extent31
dc.identifier.citationNutrients 2023, 15, 1424
dc.identifier.doihttps://doi.org/10.3390/nu15061424
dc.identifier.eissn2072-6643
dc.identifier.urihttp://hdl.handle.net/10201/208301
dc.languageeng
dc.publisherMDPI
dc.relationThis research was funded by the Spanish Ministry of Science and Innovation, grant number AGL2020-120660RA-I00, and Fundación Séneca–Murcia Regional Agency for Science and Technology (Comunidad Autónoma de la Región de Murcia, CARM), through the grant number 20855/PI/18. VNG has a postdoctoral contract (20733/FPI/18) from the “Fundación Séneca” (Agencia de Ciencia y Tecnología de la Region de Murcia, CARM). NB is granted by a “Juan de la Cierva Incorporación” (IJC- 2020–044496-I) post-doctoral contract funded by MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR. GDP, PM and DDR received funding from the Ministero delle Politiche Agricole Alimentari e Forestali (MIPAAF, ID 1160), while MA and CM from the French Agency of National Research (ANR, grant 19-HDH2-0002-01), as part of the FoodPhyt project, under the umbrella of the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL) (2019–02201) and of the ERA-NET Cofund HDHL INTIMIC (GA N 727565 of the EU Horizon 2020 Research and Innovation Programme).
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/15/6/1424
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGlucosinolates
dc.subjectBreakdown products
dc.subjectMetabolism
dc.subjectBioactivity
dc.subjectHumans
dc.subjectClinical trials
dc.subjectEpidemiological evidence
dc.subject.odsObjetivo 3: Salud
dc.titleSystematic review on the metabolic interest of glucosinolates and their bioactive derivatives for human health
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublicationfdf153ef-93ee-4a1b-ba38-09ddacc8155a
relation.isAuthorOfPublication.latestForDiscoveryd08b1603-cdd3-45ea-a1a6-3d10fd8f8051
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