Publication: GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression
Authors
Sun, Suohui ; Guo, Hui ; Liang, Nan ; Wu, Tao ; Zhang, Chunpu ; Li, Huaqing
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-407
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info:eu-repo/semantics/article
Description
Abstract
Background. Glioma is the most prevalent
brain tumors with extremely poor prognosis, but the
prognostic biomarkers of high-grade (grade III and IV)
gliomas (HGG) are still insufficient.
Materials and methods. In our study, we investigated
the expression of GPBAR1 in HGG by qRT-PCR and
immunohistochemistry (IHC), and evaluated the clinical
significance of GPBAR1 with univariate and
multivariate analyses. By retrieving the data from
TCGA, we screened the genes significantly associated
with GPBAR1, and identified the correlation between
GPBAR1 and MAFB. By experiments in vitro, we
showed the pivotal role of MAFB in GPBAR1-induced
proliferation of HGG.
Results. GPBAR1 expression in HGGs was
significantly higher than that in normal brain tissues.
GPBAR1 was an independent prognostic biomarker of
HGG. GPBAR1 promoted the proliferation of HGG by
inducing MAFB expression. MAFB was also a
prognostic biomarker of HGG, and patients with coexpression of MAFB and GPBAR1 had worse
prognosis.
Conclusions. GPBAR1 promoted the proliferation of
HGG by inducing MAFB expression. Both GPBAR1
and MAFB were prognostic biomarkers of HGG, and
patients with co-expression of MAFB and GPBAR1 had
worse prognosis than those with only GPBAR1 or
MAFB expression.
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Citation
Histology and Histopathology Vol. 37, nĀŗ3 (2022)
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Este Ćtem estĆ” sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/