Publication: Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease
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Date
2002
Authors
Mesa, F.L. ; Aneiros, J. ; Cabrera, A. ; Bravo, M. ; Caballero, T. ; Revelles, F. ; Del Moral, R.G. ; O’Valle, F.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Hyaluronic acid (HA) is the most abundant
glycosaminoglycan of high molecular weight in the
extracellular matrix of soft periodontal tissues. Our
group recently demonstrated an HA-induced reduction in
lymphoplasmocyte inflammatory infiltrate in periodontal
disease.
The objective of this study was to determine the
effect of an HA gel of high molecular weight on cell
proliferation, inflammation, and different periodontal
lesion parameters.
A double-blind clinical trial was conducted on the
effect of an HA gel on cell proliferation in gingival
biopsies from 28 patients with periodontal disease. A
split-mouth design was used, randomly applying the gel
to one quadrant and a placebo to the contralateral one. A
gingival biopsy was taken for histopathological and
immunohistochemical study, in order to determine the
expression of cell proliferation antigen Ki-67 and to
evaluate the inflammatory infiltrate.
HA gel treatment induced a significant reduction in
the proliferation index of the gingival epithelium, with
276 (range 234-317) Ki-67-positive cells per mm2 in
treated samples versus 514 (range 158-876) per mm2 in
controls (Mann-Whitney U test, p<0.003). In 13 patients,
the number of Ki-67-positive fibroblastic cells was
reduced by the treatment, whereas in 6 patients no
differences were found (global difference, p=0.12). In 10
patients, Ki-67-positive cells were decreased in chronic
inflammatory infiltrate present in the lamina propria,
whereas in 6 patients no differences were found (global
difference, p=0.054).
We conclude that high molecular-weight HA gel
reduces cell proliferation in epithelial cells such as
fibroblasts and lymphocytes, abates the inflammatory
process, and improves the periodontal lesion in patients
with chronic periodontitis.
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