Publication: Rabbit pasteurellosis: Respiratory and renal
pathology of control and immunized rabbits
after challenge with Pasteurella multocida
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Date
1989
Authors
Al-Lebban, Z.S. ; Kruckenberg, S. ; Coles, E. H.
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Publisher
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gross and microscopic lesions of
pasteurellosis were studied in control and immunized
pasteurella-free rabbits after challenge with virulent
Pasteurella multocida. Pathologic responses were
compared in rabbits immunized intravenously or
mucosally with P. multocidaor with J5, a cross protective
core LPS mutant of E. coli Al1 rabbits were challenged
conjunctivally with approximately 2xLD,, of P.
multocida. Rabbits were necropsied and examined for
histopathology of the respiratory tract and kidneys. Lung
lesions varied in severity depending on the duration of
the disease, the route of vaccination, and the vaccine
used. The most severe lung lesions occurred in rabbits
vaccinated intravenously with P. multocida and
challenged with the same strain. Some of these rabbits
had purulent bronchopneumonia and pleuropneumonia.
Lung lesions were absent or less severe in rabbits
vaccinated by a mucosal (aerosol, conjunctival) roiite
and in unvaccinated controls. In these animals there was
no bronchopneumonia or pleuropneumonia, and
bronchiolitis, if present, was less severe. Kidney lesions
were found only in rabbits vaccinated intravenously.
There was an interstitial nephritis. some collagen
deposition. mononuclear cell infiltration, and a loss of
tubular architecture in the cortex. Some glomeruli were
affected.
These results indicate that intravenous immunization
contributes to the formation of lesions whereas mucosal
immunization prevented lesion formation to some
degree.
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