Publication: Human IgA nephritis, immunocytochemical evidence
Authors
Yoshioka, K. ; Maki, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This overview summarizes recent
information concerning the biopathology of mesangial
cell proliferation and matrix expansion which constitute
fundamental features in human IgA nephritis. The
currently available knowledge. mainly stemming for
immunohistochemical observation of human materials,
experimental investigations with laboratory animals, and
mesangial cell culture studies, emphasizes the
importance of cell to cell, cell to soluble factors, and cell
to matrix interactions. Mesangial cells, activated by
cytokines and growth factors, express adhesion
molecules, stimulate proliferation both of themselves
and neighbouring cells, and synthesize extracellular
matrix. Matrix components, in turn, may influence the
behaviour and proliferation activity of mesangial cells,
or act as a receptor or reservoir for growth factors.
Expression of protooncogenes, regulating cell
proliferation and apoptosis, by glomerular cells could be
associated with persistent cell replication and chronic
tissue damage. These disease processes seem to be
common to a group of diseases termed chronic
inflammatory proliferative disorders.
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Citation
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