Publication: Extracellular vesicle-mediated modulation of angiogenesis
Authors
Gai, Chiara ; Carpanetto, Andrea ; Deregibus, Maria Chiara ; Camussi, Giovanni
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-708
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info:eu-repo/semantics/article
Description
Abstract
Angiogenesis is a tightly regulated process
where a number of different players are involved.
Recently, a role for membrane vesicles actively released
from cells has been proposed. Virtually all cell types
may release non-apoptotic membrane vesicles in the
nano-size range containing critical components of the
cell of origin. The two main categories of these vesicles
include exosomes and microvesicles that differ for
biogenesis but, sharing several features and mechanisms
of action, have been collectively named extracellular
vesicles (EV). EV are able to transfer from one cell to
another bioactive lipids, proteins and nucleic acids that
may induce changes in the phenotype and functions of
the recipient cells. This new mechanism of cell to cell
communication has been involved in modulation of the
angiogenic process. Tumor cells, inflammatory cells and
stem/progenitor cells were shown to release EV with
angiogenic properties, suggesting that they may act on
vascular remodeling in different physiological and
pathological conditions. In this review we discuss the
evidence for the role and the mechanisms of action of
EV in vascular homeostasis and in the angiogenic
processes occurring in tumors, inflammation and tissue
regeneration.
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Citation
Histology and histopathology: Vol.31, nÂş4 (2016)
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