Publication: Coexistence of reactive plasticity and neurodegeneration in Alzheimer diseased brains
Authors
Guevara, J. ; Dilhuydy, H. ; Espinosa, B. ; Delacourte, A. ; Quirion, R. ; Mena, R. ; Joanette, Y. ; Zenteno, E. ; Robitaille, Y.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Alzheimer’s disease (AD) is a pathological
process characterized by neuron degeneration and, as
recently suggested, brain plasticity. In this work, we
compared the reactive plasticity in AD brains associated
to O-glycosydically linked glycans, recognized by
lectins from Amaranthus leucocarpus (ALL) and
Macrobrachium rosenbergii (MRL), and the tau neuritic
degeneration. The neuritic degenerative process was
evaluated by the quantification of aggregated neuritic
structures. Lesions were determined using antibodies
against hyperphosphorylated-tau (AD2), amyloid-ß, and
synaptophysin. In these conditions, we classified and
quantified three pathological structures associated to the
neuritic degenerative process: 1) Amyloid-ß deposits
(AßDs), 2) Classic neuritic plaques (NPs), and 3)
Dystrophic neurites clusters (DNCs) lacking amyloid-ß
deposits. Reactive plasticity structures were constituted
by meganeuritic clusters (MCs) and peri-neuronal
sprouting in neurons of the CA4 region of the
hippocampus, immunoreactive to synaptophysin
(exclusively in AD brains) and GAP-43. Besides, MCs
were associated to sialylated O-glycosydically linked
glycans as determined by positive labeling with ALL
and MRL. Considering that these lectins are specific for
the synaptic sprouting process in AD, our results suggest
the co-occurrence of of several areas of reactive
plasticity and neuron degeneration in AD.
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