Publication: Pulmonary expression of vascular endothelial growth factor (VEGF) and alveolar septation in a newborn rat model exposed to acute hypoxia
and recovered under conditions of air or hyperoxia
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Date
2009
Authors
Remesal, Ana ; Pedraz, Carmen ; San Feliciano, Laura ; Ludeña, Dolores
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vascular endothelial growth factor (VEGF) is
an endothelial cell growth factor expressed in normal
lung tissue. The aim of the study was to investigate the
expression of VEGF and its repercussions as regards
alveolarization in the developing rat lung. We studied
pulmonary VEGF expression at 0 and 14 days of life in
Wistar rats. Rat pups were exposed to hypoxia for two
hours during the first hours of life and recovered under
conditions of hyperoxia or normoxia for a further two
hours, or not recovered. The animals of the control
group were only exposed to conditions of normoxia. Our
results showed that VEGF was increased in the lungs of
the animals that were exposed to hypoxia but we did not
find any correlation with the septation. The VEGF was
decreased in the lungs of animals exposed to hyperoxia
after neonatal hypoxia. We observed this at 0 and 14
days of life, and it was correlated with a lower degree of
alveolarization at 14 days of life. Our data suggest that
hyperoxia after neonatal hypoxia at birth may give rise
to a decrease in the expression of VEGF, possibly
permanently, together with a reduction in alveolar
development.
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