Publication: Corticosterone 21-acetate in vivo induces acute stress in chicken thymus:
cell proliferation, apoptosis and cytokine responses
Authors
Franchini, A. ; Marchesini, E. ; Ottaviani, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In vivo effects of acute stress induced by
corticosterone 21-acetate in male Gallus domesticus
thymus are studied and the steroid actions are evaluated
in terms of cell proliferation, apoptosis and cytokine
response in 10- and 21-day-old chickens. Steroid
treatment induced thymocyte apoptosis and cell death
decreased in the cortical-medullar direction and was
more evident in younger animals. 24 h after treatment,
the observed effect was reversed. The mitotic activity
and thymic cells containing cytokine-like molecules
were also affected. Indeed, the acute stress stimulated
cytokine immunoreactivity to anti-IL-1a, IL-6 and TNF-
a antibodies both in epithelial cells and interdigitating
cells located in medullar and cortical-medullar regions.
The increased cytokine expression observed after 12 h
was maintained after 24 h. The comparison between 10-
and 21-day-old chickens showed a lower number of cells
containing cytokine-like molecules in younger
specimens. The present findings suggest that cytokines
activated by acute stress in vivo could contribute to
restoring immunological homeostasis and influence
thymic glucocorticoid-mediated functions.
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